Livedoid vasculitis - 청피반성 혈관염
청피반성 혈관염 (Livedoid vasculitis)은 청년에서 중년 여성에게 주로 나타나는 만성 피부 질환이다. 이 질환의 특징을 설명할 때 사용되는 표현 중 하나는 “하지에 망상 패턴을 보이는 통증성 자색 궤양”(보라색)이다. 이는 만성 정맥 고혈압 및 정맥류 등 여러 질환과 관련이 있다.
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2022년 독일의 Stiftung Warentest 결과에 따르면 ModelDerm에 대한 소비자 만족도는 유료 원격진료 상담보다 약간 낮았습니다.
2022년 독일의 Stiftung Warentest 결과에 따르면 ModelDerm에 대한 소비자 만족도는 유료 원격진료 상담보다 약간 낮았습니다.
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relevance score : -100.0%
ReferencesLivedoid vasculopathy은 다리 아래쪽에 지속적인 통증을 동반한 궤양이 발생하는 희귀한 피부 질환입니다.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy은 다리 아래쪽에 재발성 궤양을 일으키고, 위축성 블랜치라 불리는 창백한 흉터를 남기는 희귀 피부 질환입니다. 정확한 원인은 아직 밝혀지지 않았지만, 혈액 응고 증가 (hypercoagulability)가 주요 요인이고 염증은 부차적인 역할을 하는 것으로 여겨집니다. 혈전 형성에 기여하는 요인으로는 단백질 C·S 결핍, factor V Leiden과 같은 유전적 돌연변이, antithrombin III 결핍, 프로트롬빈 유전자 변이, 고동맥동(동맥) 혈중 호모시스테인 수치 상승 등이 있습니다. 생검에서는 혈관 내 혈전, 혈관벽 비후, 그리고 흉터가 관찰됩니다. 치료는 항혈소판제, 항응고제, 섬유소 용해 요법 등 혈전 예방에 중점을 둔 다각적 접근을 포함합니다. 이 질환에 사용할 수 있는 약물로는 colchicine 및 hydroxychloroquine, 혈관확장제, 면역억제제 등이 있습니다.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy은 양쪽 다리에 병변이 나타나는 드문 질환입니다. 작은 혈관에 혈전이 형성되는 것은 혈관 내벽 손상과 함께 응고가 증가하고 혈전 분해가 감소하여 발생하는 것으로 생각됩니다. 주로 여성, 특히 15~50세 사이에서 더 흔합니다. 금연, 상처 관리, 혈액 희석제 및 항혈소판제와 같은 약물 사용이 효과적이었습니다.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
